Testosterone Cypionate is a slow acting injectable ester of the primary male androgen testosterone. Testosterone is also the main anabolic hormone in men and is the basis of comparison by which all of the other anabolic/ androgenic steroids are being judged. Exactly as with all other injectable testosterone forms, testosterone cypionate is very favored by a lot of athletes because of its ability to offer huge increases in muscle mass and in strength.
Except for everything mentioned above, is fairly important to mention here that in the time there’s a large number of some other steroidal compounds out there that have been made available since the appearance of injectable testosterones, they are still considered to be the dominant (some of the most important) bulking agents among bodybuilders and this is a compound that is very widely used worldwide. There’s just very little argument that these are among the most powerful mass drugs available with testosterone cypionate being included here. The chemical names include: 4-androsten-3-one-17beta-ol, 17beta-hydroxy-androst-4-en-3-one. The active life is considered to be up to 8 days while the detection time is up to 3 months.
In the article below, you will be able to find information to the following questions:
What is Testosterone Cypionate?;
Where to Buy Testosterone Cypionate?;
What’s the Difference Between Testosterone Cypionate, Enanthate and Propionate?;
Testosterone Cypionate Dosage and Cycle;
Testosterone Cypionate Half Life;
Estrogenic Side Effects of Testosterone Cypionate
Testosterone is very well known to be readily aromatized in the body to estradiol (estrogen hormone). The aromatase (estrogen synthetase) enzyme is the one responsible for that metabolism of testosterone. The high estrogen levels can cause the side effects like for example the increased water retention, gynecomastia as well as body fat gain which may sometimes lead to high blood pressure. Even so, testosterone is still considered to be a moderately estrogenic steroid.
In order to deal with the elevated estrogen levels and estrogen related side effects, some men might need to use an anti estrogen like for example tamoxifen citrate or clomiphene citrate. More often than not, this is enough to mitigate estrogen related side effects but there are still situations in which the individual might need a stronger alternative – an AI (Aromatase Inhibitor).
However it is still recommended to use the anti estrogen first and in case it doesn’t work to use an AI like for example Arimidex (anastrozole) as an alternative. The reason why is better to use an anti estrogen than an AI is because generally, AI’s are much more expensive and plus to that, they might have a negative effect on the blood lipids.
It is important to understand that the estrogenic side effects are highly dose dependent which means that they would occur depending on the dosage that the individual uses. At small doses the individual might not get any side effects at all. However with some higher doses (and especially those that are considered mega/ over dosing of testosterone cypionate is more likely to require the use of an anti estrogen or even aromatase inhibitor for more sensible people.
Plus, due to the fact that water retention as well as loss of muscle definition are common side effects, especially with higher doses of testosterone (either cypionate, enanthate or propionate), the compound is usually considered to be a poor choice for dieting or for cutting cycles of training.
Nonetheless, this is usually a mistake that people make as it can be a great gear for cutting phases either. However, its moderate estrogenecity is making this product be an ideal steroid for the bulking cycles in the time when the extra water retention is going to be helpful in supporting raw strength and muscle size as well as to help to foster a stronger anabolic environment.
Androgenic Side Effects of Testosterone Cypionate
Testosterone is a hormone and is the primary male androgen which is having an extremely strong connection with male sexual characteristics as this androgen is responsible for maintaining these characteristics. Nonetheless, people with high levels of testosterone are very likely to produce the androgenic side effects where acne, oily skin as well as body and/ or facial hair growth are included. Plus to that, those men that are having a genetic predisposition for hair loss (androgenetic alopecia) may also notice accelerated male pattern balding. If this is a concern for you and you are predisposed to get this condition, it is better to avoid the steroid.
Being a powerful androgen, Testosterone Cypionate is not recommended to women’s use. That’s because virilization symptoms will most likely appear which includes: clitoral enlargement, a deepening of vocal chords, menstrual irregularities, facial hair growth and others. The symptoms might become permanent if continuous use is applied. Generally, this product is not recommended for women’s use. That’s because it is believed that the virilizing symptoms would appear as soon as a woman would start using the compound but it is strongly recommended to stop using the compound at the first symptom in order to avoid getting them permanent.
Keep in mind that in androgen- responsive target tissues like for example scalp, skin and prostate the high relative androgenicity of testosterone is dependent on its reduction to dihydrotestosterone (DHT). The 5-alpha reductase enzyme is being responsible for that metabolism of testosterone. The use of finasteride or dutasteride (5 alpha reductase inhibitor) concurrently is going to interfere with site specific potentiation of testosterone action and this is lowering the tendency of testosterone drugs to produce the androgenic side effects.
It is also very important to keep in mind that the anabolic and the androgenic effects are both mediated via the cytosolic androgen receptor. This is the reason why the full separation of testosterone’s anabolic and androgenic properties is not being possible and that’s even with the total 5 alpha reductase inhibition.
Hepatotoxicity Side Effects of Testosterone Cypionate
As it has been discovered, testosterone is having absolutely no hepatotoxic effects and for this reason, liver toxicity is very unlikely to happen while administering Testosterone Cypionate or any other form of testosterone. There’s a study out there which has examined the potential for hepatotoxicity with high doses of testosterone by administering 400 mg of this hormone per day (which means it has been administered a total of 2,800 mg per week) to a group of male subjects.
The steroid has been used orally because in this way higher peak concentrations would be reached in hepatic tissues compared to the intramuscular injections. This compound has been given every day for a total of 20 days and even so, it has produced barely any changes (nothing significant) to liver enzyme values including alanine – amino – transferase, bilirubin, serum albumin as well as alkaline phosphatases.
With all of this being said, even the most sensitive individuals, hepatotoxicity should not be a problem. Keep in mind that testosterone alone doesn’t give any liver toxicity, however if this product is being taken alongside a product that might stress the liver – Testosterone Cypionate (or any other form of testosterone) definitely won’t be helpful in such a case. Liver enzymes should be monitored in such a situation.
Cardiovascular Side Effects of Testosterone Cypionate
A negative impact that this steroid is going to offer is on the serum cholesterol which can become a problem. All of the anabolic/ androgenic steroids are having negative impacts on the serum cholesterol and testosterone cypionate is not an exception.
The use of testosterone is affecting the HDL cholesterol (good cholesterol) numbers by decreasing them and in the same time is increase the LDL (bad cholesterol) numbers and this is very often changing the HDL to LDL balance into a negative way, where there’s a bigger risk of suffering from arteriosclerosis. If you’re thinking about using a steroid remember that the relative impact on an anabolic or androgenic steroid on the serum lipids is depending on a few different factors, some of them are: the dose you are using (the smaller the safer), the route of administration (either is oral or injectable – orals are always worse here), on the level of resistance to hepatic metabolism as well as on the type of the steroid (either is aromatizable or non aromatizable).
But in the end, in case you have some cholesterol issues, it is not recommended to use any steroids at all. Keep in mind that anabolic/ androgenic steroids can also have a negative impact on the blood pressure and on the triglycerides, they may reduce endothelial relaxation, they may help with left ventricular hypertrophy and all of this can increase the risk of suffering from cardiovascular disease as well as myocardial infarction.
The good news is that talking about testosterone itself, this compound does not seem to be very significant in most of the cases. The good news is that it does not seem to be very significant in most of the cases. Nonetheless, when this compound is being taken in combination with the use of some AI (aromatase inhibitors) then it does seem that the negative effect is getting worse.
There’s a study which was done where 280 mg of testosterone ester (enanthate) per week has been given and it had only a little but definitely nothing statistically significant effect on the HDL cholesterol after keeping this dosage schedule for 12 weeks, however when it has been taken the same way but with an added aromatase inhibitor then a really strong decrease has been noticed (a decrease of 25%). Those studies that are using 300 mg of testosterone ester (enanthate) per week for a total of 20 weeks without an aromatase inhibitor has shown a decrease of only 13% in the HDL cholesterol. Then, when the dosage has been higher – 600 mg per week, then the reduction has reached 21%. There are other steroids out there which are offering a lot much less negative effects than these.
The negative impact of the aromatase inhibitors also should be taken in consideration before someone would decide to add it to the testosterone therapy. In case you already notice cholesterol issues while being on testosterone alone, it is highly recommended to avoid adding the aromatase inhibitor to your plan.
Due to the positive effects of the estrogen on the serum lipids, tamoxifen citrate or clomiphene citrate are being much more preferred to aromatase inhibitors for those people who are being worried about the cardiovascular health and that’s because they are giving a partial estrogenic effect in the liver. This is allowing them to potentially improve the lipid profiles as well as to offset some of the negative effects of the androgens either. With the doses that are as high as 600 mg or less of testosterone per week, the impact on the lipid profile, although is still noticeable, it is definitely not dramatic and that’s why, in most cases, an anti estrogen drug (for cardio protective purposes) is unnecessary. Even though there are people who might still need it, usually – more sensitive individuals or those using high doses.
In addition to that, doses of 600 mg per week or less than this also have failed to give any statistically significant changes in the LDL/ VLDL cholesterol, in the C reactive protein, triglycerides, apolipoprotein B/C-III as well as insulin sensitivity, all of which is indicating a pretty weak impact on the cardiovascular risk factors, although they still shouldn’t be excluded. When the steroid is being used in moderate doses, the injectable testosterone esters are most commonly thought to be the safest of all the anabolic/ androgenic steroids out there.
It is recommended not to use this steroid beforehand if you have cholesterol issues. Plus to that, it is recommended to have a cholesterol friendly lifestyle which includes a lot of cardiovascular exercise program and a healthy diet where omega fatty acids are added (fish oils) and saturated fats as well as simple sugars are excluded or at least limited. Using an antioxidant can be helpful as well. It is recommended to keep this healthy lifestyle during the entire period while on the steroid.
Testosterone Cypionate and Natural Testosterone Suppression Side Effect
It is extremely important to know: it doesn’t matter what is your tolerance, why you are using testosterone (cypionate or whatever other) and what’s the dosage you take – Testosterone is going to suppress the natural testosterone production in every men. It is considered that any anabolic/ androgenic steroid taken in doses enough to promote muscle growth is going to give the testosterone suppression. The higher the dosage taken the higher the suppression rate, but even with low doses it will still suppress the natural testosterone production. During the administration with testosterone, the user is obviously going to get enough testosterone, but this becomes a problem when the administration is stopped.
When the user stops using Testosterone Cypionate (or any other form of testosterone), the body is not getting testosterone and the natural testosterone is suppressed resulting in low testosterone condition until the natural production comes back to normal.
It is also the moment when natural testosterone is going to re start but until it would reach the normal levels is required from one to 4 months, sometimes up to a year. This is the main reason why the users are highly recommended to implement a PCT (post cycle therapy) plan as soon as they stop using testosterone. This would allow them to get a faster recovery and boost the natural testosterone production.
Testosterone Cypionate Administration For Men
In order to treat androgen insufficiency, there are prescribing guidelines which are calling for testosterone cypionate dosage of 50 to 400 mg taken every 2 to 4 weeks. The prescribing guidelines says that the compound should be taken so infrequently because of the fact that the cypionate ester is allow for a very slow release of the testosterone in the body from the injection site.
Nonetheless, Testosterone Cypionate is being administered (injected) on a weekly basis when is being used for physique or performance enhancing reasons, and that’s even though this steroid is remaining active in the body for a longer period of time that a week. The reason is to keep stable levels in the blood. Typically, the most common dosage is anywhere in the rage of 200 mg to 600 mg per week as this is a dosage considered low enough to be tolerated by most men and in the same time is high enough in order to offer the desired/ expected results.
It doesn’t matter what is the weekly dosage that you decide to use, testosterone should be taken in cycles anywhere between 6 to 12 weeks in length. That type of level is going to be enough for most of the users to notice they have amazing gains in their muscles size and strength while this dosage should be well tolerated by most men.
Testosterone is usually added to the bulking phases of training when the added water retention is not a huge side effect, when the user is not concerned about water retention but needs raw mass. There are still some people who do incorporate the drug into the cutting cycles either, however it is usually including some lower doses (from 100 mg to 200 mg per week) and that’s when is being accompanied by an aromatase inhibitor in order to keep the estrogen levels under control.
Very often, testosterone cypionate (or any other) is a very effective anabolic drug and is very often used with great benefit. But due to the fact that this product is very versatile (testosterone), it can be combined with a lot of anabolic/ androgenic steroids in order to get the desired effects. Like for example, it can be very well stacked with boldenone undecylenate, nandrolone decanoate or methenolone enanthate (200 to 400 mg per week of whatever) in order to get great effect without significant hepatotoxicity.
Most often than not, for the performance enhancement purposes, one injection per week it is just enough, nonetheless, in a lot of the cases, people still decide to split it into 2 smaller and equal sized injection to inject per week as this is going to provide far more stable blood levels and therefore is considered to be more efficient. As in terms for the actual performance doses, the dosage can vary quite a lot in the range anywhere from 200 mg per week all the way up to 1000 mg per week, it all depends on the desired results, on the needs and on the personal tolerance.
It is said that doses above 750 mg – 1000 mg is not so well tolerated by so many men, especially those that are over 1000 mg per week. In fact, doses that are under 1000 mg per week are thought to be beneficial and still tolerated by most men, however “over dosing” with more than 1000 mg per week is considered to be unhealthy and not efficiently as few people would tolerate such a high dose but it barely gives any further benefits when supplementing further 1000 mg per week. With this being said, generally, this practice of “mega – over” dosing is considered unhealthy and not recommended.
Testosterone Cypionate Administration For Women
Testosterone Cypionate is extremely rarely being used in women in clinical medicine and that’s because there are other products which are considered safer alternatives. When it is being applied, it is most often being used as a secondary medication during the inoperable breast cancer and that’s when some other therapies have failed to produce a desirable effect and the suppression of the ovarian function is required.
Testosterone Cypionate is not a recommended product for women for the physique and/ or performance enhancing reasons and that’s because of its very strong androgenic nature, due to its tendency to produce virilizing side effects as well as the slow acting characteristics – very slowly releasing the testosterone hormone from the injection site (and therefore this is making the blood levels be very difficult to control).
There are much safer alternatives for women searching for steroids for physique and/ or performance enhancing purposes. Testosterone Cypionate from our site is guaranteed to offer you amazing result.